TABLE 3.
Neutralization of SBBC virus isolates by plasma samples derived from the nef-attenuated and control groupsa
| Virus | Plasma | Yr postinfection | ID50 | ID80 |
|---|---|---|---|---|
| HIV-1D36III | D36III/VIII | 14.5/16.4 | 2,510/1,723 | <100/<100 |
| C18(2)/(4) | 9.8/10.5 | 818/1,091 | <100/<100 | |
| C49I | 17.0 | NT | NT | |
| C54IV/VIII | 10.9/15.6 | 314/216 | <100/<100 | |
| C64IV/XII | 12.9/16.0 | <100/<100 | <100/<100 | |
| C98IV/XIV | 14.0/17.8 | <100/<100 | <100/<100 | |
| C135I | 19.6 | NT | NT | |
| Nef1(1) | 18.5 | NT | NT | |
| HIV-1C18(2) | D36III/VIII | 14.5/16.4 | 674/836 | 150/157 |
| C18(2)/(4) | 9.8/10.5 | 904/945 | <100/<100 | |
| C49I | 17.0 | <25 | <25 | |
| C54IV/VIII | 10.9/15.6 | <100/<100 | <100/<100 | |
| C64IV/XII | 12.9/16.0 | <100/<100 | <100/<100 | |
| C98IV/XIV | 14.0/17.8 | <100/<100 | <100/<100 | |
| C135I | 19.6 | <25 | <25 | |
| Nef1(1) | 18.5 | 1,266 | 315 | |
| HIV-1C18(2) | S1 | 8.2 | 2,299 | <100 |
| S2 | 10.9 | 2,710 | 353 | |
| S4 | 9.9 | 1,398 | <100 | |
| S12 | 10.6 | 709 | <100 | |
| S13 | 5.2 | 2,661 | 703 | |
| Seronegative | N/A | <25 | <25 |
a
Plasma samples derived from members of the nef-attenuated and control cohorts were tested for neutralization of two SBBC isolates, HIV-1D36III and HIV-1C18(2). The plasma samples were tested at twofold dilutions from 1:100 to 1:3,200, except for C49I, C135I, and the seronegative plasma (1:25 to 1:800). Fifty percent or 80% inhibitory dilutions (ID50 or ID80) are shown as the reciprocal of the plasma dilution calculated to cause 50% or 80% neutralization.