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Stimulation of poliovirus virion production in vitro by 3CD. Poliovirus RNA (vRNA) alone or in combination with RNA coding for wt 3CD or the F441S or F441I 3CD mutant were translated and replicated in HeLa S10 extracts for 12 to 15 h. Formation of infectious virus was determined by plaque assay on HeLa cells monolayers. Error bars indicate standard deviations.
