TABLE 1.
Modulation of p63 target genesa
| Name | Description | Accession no. | Relative activation (n-fold)
|
|
|---|---|---|---|---|
| Microarray | RT-PCR | |||
| COL1A1 | Collagen, type I, alpha 1 | AW577407 | 2.2 | ND |
| COL4A6 | Collagen type IV, alpha 6 | D21337 | 2.5 | ND |
| COL5A1 | Collagen, type V, alpha 1 | BC008760 | 2.2 | 3 |
| COL7A1 | Collagen, type VII, alpha 1 | W68588 | 2.8 | ND |
| COL8A1 | Collagen, type VIII, alpha 1 | NM_001850 | 3 | ND |
| COL9A3 | Collagen, type IX, alpha 3 | BE731782 | 2.3 | ND |
| COL14A1 | Collagen, type XIV, alpha 1 | AA011417 | 2.6 | ND |
| LAMA1 | Laminin alpha 1 | N62886 | 2.2 | ND |
| LAMB2 | Laminin B2 | NM_002292 | 3 | 3.2 |
| FAT | FAT tumor suppressor homolog 1 | W57946 | 2.4 | 2.4 |
| FN1 (×2)b | Fibronectin | AW385690 | 2.5 | 1.8 |
| FBN1 (×2)b | Fibrillin 1 | NM_000138 | 2 | 2.3 |
| FBN2 | Fibrillin 2 | AA452111 | 2 | ND |
| SERPINE1 | Serine proteinase inhibitor E1 | BE812315 | 2 | ND |
| SERPINI1 | Serine proteinase inhibitor I1 | NM_005025 | 2.8 | ND |
a
According to reference 5. The activation of p63 target genes in E2-expressing cells compared to GFP-expressing cells is given as well as the values of RT-PCR experiments done in cells expressing or not expressing E2. Genes in boldface were found modulated in previous microarray experiments (41).
b
Genes present twice in the microarray.