TABLE 3.
Modulation of cell cycle genes in cervical cancers biopsies
| Biopsy lesion no. | HPV typea | Level of transcription in cancer biopsies relative to normal adjacent tissue (n-fold)b
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cdc20 | STK12 (Aurora A) | ESPL1 (Separin) | STK18 | Cdc25A | BRRN1 | CKS1 | CKS2 | CENPA | SPBC25 | ||
| I | 16 | 2.5 | 1.6 | 0.7 | 2.2 | 1.2 | 2 | ||||
| II | 16 | 2 | 3 | 0.5 | 4.8 | 1.2 | 3 | ||||
| III | 16 | 5 | 2.7 | 1 | 3 | 2.8 | 3.5 | ||||
| IV | 31 | 4 | 12 | 6 | 3 | 8 | 1.8 | ||||
| V | 45 | 3.5 | 1.2 | 0.6 | 1.2 | 1.2 | 3 | ||||
| VI | 18 | 3.2 | 3.4 | 1 | 5.5 | 0.8 | 6 | 2.5 | 3 | 3.9 | 1.7 |
| VII | 33 | 5.4 | 4.7 | 0.8 | 3.3 | 1.5 | 3.5 | 2.9 | 6.7 | 9 | 3.6 |
| Meanc | 3.6 | 4.1 | 1.5 | 3.3 | 2.4 | 3.3 | |||||
a
HPV type found associated with the biopsies as determined by RT-PCR.
b
Values are mean levels of transcription in cancer biopsies compared to normal adjacent tissue.
c
Mean values were calculated from the six independent samples. The associated P values were 0.008 (Cdc20), 0.008 (STK12), 0.3 (ESPL1), 0.008 (STK18), 0.015 (Cdc25A), and 0.008 (BRRN1) as calculated with GraphPad Prism, version 4, software.