Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Rint-1 heterozygous mice develop multiple tumors. (A) Tumor incidence in Rint-1+/− mice. (B) PCR analysis of microdissected tumor samples showed no loss of heterozygosity in tumors developed in Rint-1+/− mice. C, wild-type mouse embryonic fibroblasts; Mut, mutant; Wt, wild type. (C) Immunostaining with anti-Rint-1 antibody detected the expression of Rint-1 protein (arrows) in mammary, lung, and liver tumors. Specimens were counterstained with methylene green (magnification, ×400).
