Amino acid sequence alignment of the amino-terminal domains of PRMT3 from multiple species. Identical amino acids are shown in black, and similar amino acids are shown in gray. The predicted zinc finger domain, the conserved region 1 (CR1) and CR2, and the PRMT-specific motif I are boxed. Asterisks are present under the canonical cysteine and histidine residues of the zinc finger motif. Sequence are from Neurospora crassa (Nc), Aspergillus nidulans (An), Homo sapiens (Hs), Drosophila melanogaster (Dm), Schizosaccharomyces pombe (Sp), Cryptococcus neoformans (Cn), and Toxoplasma gondii (Tg). Alignment and shading were generated using ClustalW and Boxshade software.