TABLE 1.
Conservation of type I and II PRMTs across simple eukaryotesa
| Organism | % Of identity to human PRMTb
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| PRMT1 | PRMT2 | PRMT3 | PRMT4 | PRMT5 | PRMT6 | PRMT7 | PRMT8 | PRMT9 | |
| Cryptococcus neoformans | 50 | ND | 32 | ? | 38 | ND | ND | ND | ND |
| Schizosaccharomyces pombe | 49 | ND | 33 | ND | 33 | ND | ND | ND | ND |
| Saccharomyces cerevisiae | 38 | ND | ND | ND | 27 | ND | ND | ND | ND |
| Candida albicans | 41 | ND | ND | ND | ND | ND | ND | ND | ND |
| Aspergillus nidulans | 46 | ND | 36 | ND | 37 | ND | ND | ND | ND |
| Neurospora crassa | 46 | ND | 33 | ND | 33 | ND | ND | ND | ND |
| Dictyostelium discoideum | 50 | ND | ND | ND | 46 | ? | ND | ND | ND |
| Leishmania major | 41 | ND | ND | ND | 23 | ? | ? | ND | ND |
| Trypanosoma brucei | 43 | ND | ND | ND | 21 | ? | ? | ND | ND |
| Toxoplasma gondii | 45 | ND | 30 | ? | 32 | ND | ND | ND | ND |
a
The amino acid sequences of human PRMT1 to PRMT9 were used as bait for BLAST searches. The search and collection of related information was performed at the following websites: NCBI (www.ncbi.nlm.nih.gov), the Wellcome Trust Sanger Institute (www.sanger.ac.uk), the BROAD Institute (www.broad.mit.edu/tools/data/seq.html), the ToxoDB (www.toxodb.org/toxo/home.jsp), and the Saccharomyces Genome Database (www.yeastgenome.org).
b
The percentages of identity were derived after amino acid sequence alignments using ClustalW (www.ebi.ac.uk/services). ND, not determined. ?, a gene product with low amino acid sequence similarity to this human PRMT has been found in this organism (see text).