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. Author manuscript; available in PMC: 2008 Apr 1.
Published in final edited form as: Heart Rhythm. 2007 Jan 7;4(5):638–647. doi: 10.1016/j.hrthm.2006.12.046

Figure 6. BayK8644–induced ST-T wave alternans in a left ventricular wedge preparation and its suppression by ranolazine.

Figure 6

Traces were simultaneously recorded from M region (upper trace) and epicardial (middle trace) sites, together with a transmural ECG (lower trace). Left: BayK8644 (1 μM, 60 minutes of exposure) induces marked ST-T wave alternans largely due to alternation of plateau voltage and action potential duration of the M cell. Right: Ranolazine (10 μM, 30 minutes of exposure) in the continued presence of BayK8644 abolishes ST-T wave alternans and alternation of M cell action potential duration. Basic cycle length (BCL) = 400 ms.