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. Author manuscript; available in PMC: 2008 Apr 1.
Published in final edited form as: Heart Rhythm. 2007 Jan 7;4(5):638–647. doi: 10.1016/j.hrthm.2006.12.046

Figure 7. BayK8644 (1 μM)-induced delayed afterdepolarizations (DADs) and its suppression by ranolazine.

Figure 7

A: DADs simultaneously recorded from epicardial and subendocardial M cells in a left ventricular (LV), arterially perfused wedge preparation stimulated at basic cycle length (BCL) = 300 ms. Alternans of ST segment on the ECG correlates with alternans of the plateau of the M cell. B: BayK8644–induced action potential duration (APD) alternans and DADs in isolated myocytes (M cells). Left: Two cells in which pacing at BCL = 450 ms in the presence of 1 μM BayK8644 caused incomplete repolarization and alternans of APD. Addition of 10 μM ranolazine reduced duration and eliminates APD alternans in these cells. Right: Two cells in which rapid pacing in the presence of 1 μM BayK8644 caused DADs, which were abolished by 10 μM ranolazine.