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. 1996 Nov 26;93(24):14193–14198. doi: 10.1073/pnas.93.24.14193

Figure 3.

Figure 3

Inclusion of the phenylalanine P-region residue in GIRK4 multimers produces “GIRK1/GIRK4-like” single-channel activity. (a) “To” comparisons (calculated from oocytes from several batches) among GIRK4 (n = 7 patches), GIRK1/GIRK4 (n = 12) and GIRK4(S143F)/GIRK4 (n = 5). (b) Single-channel currents from representative cell-attached patches from Xenopus oocytes expressing GIRK4 (n ≥ 100 patches), GIRK1/GIRK4 (n ≥ 100), and GIRK4(S143F)/GIRK4 (n = 10). The membrane was held at −80 mV. An all-point histogram plot indicates the amplitudes resulting from the various activity levels ranging from closed to multiple open levels. Data points in this and other figures are shown in a logarithmic scale ranging from 1–10,000 points.