Figure 3.

(A) Comparison of the amino acid sequences of conserved regions of Fps1 and Spo9 and other members of FPSs and GGPSs. ScBts1, S. cerevisiae GGPS, Bts1 (Q12051); AtGGPS, Arabidopsis thaliana GGPS6 (BAA23157); and HsGGPS, Homo sapiens GGPS1 (AAH05252). FARM and SARM are boxed. The GQ motif is shown in bold. The arrow indicates the fifth amino acid before the FARM motif, which is important for determination of the final product. (B) A phylogenetic tree of GGPSs and FPSs from various organisms calculated by the neighbor joining method. Fps1 and Spo9 are marked by asterisks. Abbreviations: Ag, Abies grandis; At, A. thaliana; Bm, Bombyx mori; Bt, Bos taurus; Cp, Claviceps purpurea; Dj, Dendroctonus jeffreyi; Dm, Drosophila melanogaster; Ec, E. coli; Gf, Gibberella fujikuroi; Gg, Gallus gallus; Hb, Hevea brasiliensis; Hs, Homo sapiens; Kg, Kitasatospora griseola; Kl, Kluyveromyces lactis; La, Lupinus albus; Lc, Lactarius chrysorrheus; Ld, Leishmania donovani; Mm, Mus musculus; Mp, Myzus persicae; Mt, Methanothermobacter thermautotrophicus; Nc, Neurospora crassa; Pa, Parthenium argentatum; Rn, Rattus norvegicus; Sa, Sulfolobus acidocaldarius; Sar, Streptomyces argenteolus; Sc, S. cerevisiae; Sm, Sphaceloma manihoticola; Sp, S. pombe; Tb, Trypanosoma brucei; Tg, Toxoplasma gondii; Tt, Thermus thermophilus; and Zm, Zea mays.