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. 2007 Sep;18(9):3635–3644. doi: 10.1091/mbc.E07-01-0053

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© 2007 by The American Society for Cell Biology

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Figure 6. — PKR or PERK mediates the induction of PI3K pathway in response to IFN, dsRNA or ER stress respectively. (A) PKR^+/+ and PKR^−/− MEFs were treated with mouse IFN-γ (100 IU/ml) for the indicated time points. Protein extracts (50 μg) were subjected to immunoblotting against the indicated proteins. (B and C) PKR^+/+ and PKR^−/− MEFs were transfected with dsRNA (10 μg/ml) for the indicated time points. Protein extracts (50 μg) were subjected to immunoblotting against the indicated proteins. (D) PERK^+/+ and PERK^−/− MEFs were treated with thapsigargin (TG; 1 μM) in the presence of serum for the indicated time points. Protein extracts (50 μg) were subjected to immunoblotting with phosphospecific antibodies against the indicated proteins. (A–D) Data represent one of three reproducible experiments.