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Model of PI3K activation by eIF2α kinases. Activation of the eIF2α kinases (namely PERK or PKR) leads to the translational inhibition of a protein (X) that negatively regulates PI3K activity. This leads to the activation of the downstream components of PI3K signaling as documented in this article. As explained in the Discussion, the negative regulator may act either directly on PI3K or indirectly by suppressing the activity of upstream activators of PI3K.
