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. Author manuscript; available in PMC: 2007 Aug 24.
Published in final edited form as: Mol Endocrinol. 2006 Nov 30;21(2):524–537. doi: 10.1210/me.2006-0253

Fig. 7. Effect of the COX Inhibitor, Indomethacin and PG on GnRH-Induced Gonadotropin Secretion.

Fig. 7

Rat pituitaries were pretreated with indomethacin (8 μm), PGE2, PGF2α, or iloprost (500 nm) for 4 h and further incubated with the drugs with or without GnRH (100 nm) for 3 h (Indomethacin + GnRH) and 4 h (PG + GnRH). The medium was collected and LH (A and C) and FSH (B and D) were determined by RIA. Note that indomethacin enhanced GnRH-stimulated LH, but not FSH release, whereas PGF2α, but not PGE2 or iloprost, inhibited GnRH-stimulated LH, but not FSH release. One-way ANOVA determined that **, P < 0.01 and *, P < 0.05 were significantly different between treatment groups.