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. 2007 May 4;189(14):5257–5264. doi: 10.1128/JB.00254-07

FIG. 1.

FIG. 1.

On top is shown the syntenic organization of accD1 as component of the acetyl-CoA carboxylase. Orthologous genes are colored similarly. Green is the biotin protein ligase birA; black is the paralogous accD2, which is named accD5 in M. tuberculosis (M. tub.); and red is the open reading frame encoding the ɛ-peptide. At the bottom is shown the syntenic organization of accD3, whose gene product together with accD2 of C. glutamicum is a component of the acyl carboxylase required for mycolic acid synthesis. The polyketide synthase, or condensase, ligating the two long-chain fatty acids to the mycolic acid backbone is pks in C. glutamicum (28) and pks13 in M. tuberculosis. C. glu, C. glutamicum; C. eff, C. efficiens; C. dip, C. diphtheriae; M. lep, M. leprae; M. tub, M. tuberculosis; M. sme, M. smegmatis.