TABLE 2.

Numbers of genes up- and downregulated in each of 22 COG categories in D. vulgaris wild-type cells grown in two different conditions

COG functional category	No. of genes upregulated (Up) or downregulated (Down) under the following condition:
	5% H2 vs lactate (Up)	5% H2 vs lactate (Down)	50% H2 vs lactate (Up)	50% H2 vs lactate (Down)	H2 vs lactate (Up)	H2 vs lactate (Down)	5% H2 vs 50% H2 (Up)	5% H2 vs 50% H2 (Down)
i. Translation, ribosomal structure, and biogenesis	4	45	4	25	2	25	1	8
ii. RNA processing and modification	0	0	0	0	0	0	0	0
iii. Transcription	3	3	6	4	3	2	0	1
iv. DNA replication, recombination, and repair	6	2	4	4	1	1	2	3
v. Cell division and chromosome partitioning	2	1	0	0	0	0	0	0
vi. Defense mechanisms	1	2	2	2	1	0	0	1
vii. Posttranslational modification, protein turnover, and chaperones	12	10	19	4	11	3	2	4
viii. Cell envelope biogenesis and outer membrane	11	5	15	6	3	2	4	3
ix. Cell motility and secretion	9	1	10	1	5	1	1	3
x. Signal transduction mechanisms	14	7	18	4	6	2	3	3
xi. Extracellular structures	0	0	0	0	0	0	0	0
xii. Intracellular trafficking, secretion, and vesicular transport	2	5	4	2	0	2	0	3
xiii. Energy production and conversion	32	28	28	25	13	14	14	16
xiv. Carbohydrate transport and metabolism	0	4	10	3	0	0	0	2
xv. Amino acid transport and metabolism	21	10	31	9	8	3	7	11
xvi. Nucleotide transport and metabolism	2	3	3	1	0	1	0	3
xvii. Coenzyme metabolism	7	6	10	4	6	2	1	3
xviii. Lipid metabolism	4	3	2	4	1	1	1	2
xix. Inorganic ion transport and metabolism	5	4	15	3	1	0	0	13
xx. Secondary metabolites biosynthesis, transport, and catabolism	0	0	1	0	0	0	0	0
xxi. General function prediction only	24	13	31	8	8	3	6	10
xxii. Function unknown	148	89	170	84	75	38	31	73
Totala	343	261	427	210	158	108	77	186

^aThe overall total does not count genes belonging to multiple categories more than once.