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. 2007 May 14;27(14):5128–5134. doi: 10.1128/MCB.01072-06

FIG. 3.

FIG. 3.

Enhancement of PPF at PF-PC synapses in FcγRIIB-deficient and CD3ɛ-deficient mice. Short-term synaptic plasticity at PF- and CF-PC synapses was examined by applying pairs of stimuli separated by 20 to 550 ms or 20 to 3,000 ms. The second response (expressed as a percentage of the response to the first pulse; mean ± SEM) is plotted as a function of the interpulse interval. (A and D) PPF ratios of PF-EPSCs in FcγRIIB-deficient (A) and CD3ɛ-deficient (D) PCs were calculated. PF-EPSCs were obtained by holding membrane potentials at −80 mV. (B and E) PPD ratios of CF-EPSCs in FcγRIIB-deficient (B) and CD3ɛ-deficient (E) mice. (C and F) Single innervation of PCs by CFs in 8- to 10-week-old FcγRIIB-deficient (C) and CD3ɛ-deficient (F) mice. With gradually increasing stimulus intensities applied to the CFs, more than 90% of EPSCs of the wild-type and mutant mice were obtained in an all-or-none fashion. CF-EPSCs were elicited at −10 mV to inactivate voltage-dependent channels. Numbers of tested PCs (n) are indicated in each graph. *, P < 0.05.