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(A) Nuclear localization of the TNF-α locus in primary cells. Centromere probes are shown in green (FITC), and the TNF-α locus is shown in red (Spectrum orange). Each section is between 3 and 10 μm thick. (B) Graphical representation of the proximity of the TNF-α probe to the nearest centromeric heterochromatin. Differentiation is accompanied by gradual movement from heterochromatin to euchromatin. Undiff, undifferentiated.
