TABLE 1.
Effect of p27 dose on survival of embryonic and neonatal p107-deficient animals
| Age | No. of p107-deficient animals of genotype
|
No. of litters | χ2 test P valuea | ||
|---|---|---|---|---|---|
| p27+/+ | p27D51/+ | p27D51/D51 | |||
| Neonatal day 21 | 50 | 89 | 15 | 41 | <0.001 |
| Neonatal day 1 | 34 | 38 | 16 | 11 | 0.01 |
| Embryonic day 17.5 | 13 | 11 | 7 | 5 | 0.08 |
| Embryonic day 16.5 | 10 | 28 | 15 | 7 | 0.33 |
| Embryonic day 15.5 | 10 | 22 | 12 | 5 | 0.30 |
| Embryonic day 14.5 | 17 | 30 | 18 | 10 | 0.53 |
| Embryonic day 13.5 | 7 | 21 | 5 | 5 | 0.14 |
a
The χ2 test was based on an expected Mendelian inheritance pattern for the intercrossing of p107−/− p27D51/+ mice.