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Model for the role of Erf in TSC differentiation. Erf may affect the proper initial commitment of TSCs. At a later stage elevated levels of Erf in the absence of Erk activity are required for the differentiation of chorion diploid cells to terminally differentiated syncytiotrophoblasts (Syn.Tr.), ectoplacental cone cavity closure, and chorioallantic attachment. Ch-TSC, chorion TSC.
