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. 2007 May 21;75(8):3868–3876. doi: 10.1128/IAI.00195-07

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Copyright © 2007, American Society for Microbiology

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FIG. 1. — Effects of TcdA and TcdB on Rho GTPases and on the actin cytoskeleton. (A) Autoradiography of sequential [³²P]ADP ribosylation ([³²P]ADP-ribo) of cell lysates from control HMC-1 cells and cells treated with TcdA and TcdB for 5 h. [³²P]ADP ribosylation of lysates from toxin-treated cells indicates the amount of nonglucosylated Rho GTPases. (B) Rhodamine-phalloidin staining of the actin cytoskeleton. TcdB induced a time-dependent shrinkage of cells and a reorganization of the actin cytoskeleton.