TABLE 2.
Py52/Py36-deficient sporozoites cannot infect the mammalian host
| P. yoelii parasite population | No. of injected sporozoitesa | No. of infected mice/no. of injected mice/prepatencyb | P valuec |
|---|---|---|---|
| Mouse infection | |||
| wt clone | 1.0 × 104 | 24/24/3 | |
| p52/p36-deficient Cl1 | 1.0 × 104 | 0/5/— | <0.0001 |
| p52/p36-deficient Cl2 | 1.0 × 104 | 0/58/— | <0.0001 |
| wt clone | 1.0 × 105 | 6/6/2.5 | |
| p52/p36-deficient Cl1 | 1.0 × 105 | 0/3/— | <0.1 |
| p52/p36-deficient Cl2 | 1.0 × 105 | 0/5/— | <0.01 |
| p52/p36-deficient Cl2 | 5.0 × 104 | 0/10/— | ND |
| wt clone | Mosquito bite | 3/3/d3 | |
| p52/p36-deficient Cl1 | Mosquito bite | 0/5/— | <0.1 |
| p52/p36-deficient Cl2 | Mosquito bite | 0/5/— | <0.1 |
| Rat infection | |||
| wt clone | 1.0 × 105 | 5/5/2.5 | |
| p52/p36-deficient Cl2 | 1.0 × 105 | 0/5/— | <0.01 |
a
Sporozoites were injected intravenously in the tail of mice or by mosquito bite.
b
Prepatency indicates the number of days after sporozoite injection until detection of a single erythrocytic stage by microscopic blood smear examination.
c
P values were determined by Fisher's exact test. ND, not determined.