TABLE 2.
Summary of RNA interference-mediated knockdown of endocytic factors and their known endocytic roles
| Gene | Effect on C. trachomatis entrya | Endocytic role(s)b | Reference(s) |
|---|---|---|---|
| Clathrin HC | ++ | CME | 31 |
| Hsc70 | ++ | CME | 12 |
| Caveolin-1 | − | CAV | 19 |
| Dynamin-2 | ++ | CME, CAV, PH | 25, 29, 39 |
| Rac1 | ++ | PH, MP | 13, 48 |
| Arp2 | + | CME, CAV, PH, MP | 13, 20, 44, 54 |
| RhoA | − | PH | 26 |
| Pak1 | − | MP | 18 |
| Cortactin | + | CME | 7 |
| NSF | − | CAV, PH, MP | 50, 55 |
| Calmodulin-1 | − | CME | 4 |
| Annexin II | − | CAV | 50 |
a
Results were scored as demonstrating no effect (−), some reduction (+), or strong reduction (++) in entry.
b
Known functions of these proteins in specific endocytic pathways based on current literature are also summarized: clathrin-mediated endocytosis (CME), caveola-mediated endocytosis (CAV), phagocytosis (PH), and macropinocytosis (MP).