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C4BP cofactor activity on FA19 and FA19 lgtF. C4c and C4d binding to FA19 and FA19 lgtF was compared to assess C4BP cofactor activity on the two strains. MS11 (C4BP binder, serum resistant) and MS11 lgtF (C4BP nonbinder, serum sensitive) were used as controls. A high C4d/C4c ratio indicates C4b cleavage (and C4BP cofactor activity) on the bacterial surface.
