TABLE 2.
Histology and numbers of CFU for stomachs from mice infected for 3 months with SS1 and isogenic chemotaxis mutantsa
| Infecting strain | Log CFU/g stomach | Inflammation grade | Presence of neutrophils |
|---|---|---|---|
| Wild-type SS1 | |||
| S1 | 6.57 | 3 | No |
| S2 | 7.44 | 0 | No |
| S3 | 5.51 | 1 | Yes |
| S4 | 4.6 | 1 | Yes |
| S5 | 6.3 | 2 | Yes |
| Avg | 6.82 | 1.4 ± 0.51b | |
| SS1 ΔcheY::cat-102 | |||
| Y1 | 5.05 | 1 | Yes |
| Y2 | 6.31 | 1 | Yes |
| Y3 | 7.03 | 0 | No |
| Y4 | 5.40 | 1 | Yes |
| Y5 | 5.44 | 1 | Yes |
| Avg | 6.42 | 0.8 ± 0.20 | |
| SS1 ΔtlpA::cat-1 | |||
| A1 | 7.22 | 1 | Yes |
| A2 | 4.96 | 1 | Yes |
| A3 | 5.65 | 1 | Yes |
| A4 | 6.89 | 0 | No |
| A5 | 5.72 | 1 | Yes |
| Avg | 6.7 | 0.8 ± 0.2 | |
| SS1 ΔtlpB::cat | Yes | ||
| B1 | 7.15 | 1 | Yes |
| B2 | 6.09 | 1 | Yes |
| B3 | 5.12 | 1 | Yes |
| B4 | 7.27 | 1 | No |
| B5 | 4.80 | 1 | Yes |
| Avg | 6.83 | 1.0 ± 0 | |
| SS1 ΔtlpC::cat-1 | |||
| C1 | 5.57 | 1 | Yes |
| C2 | 5.83 | 3 | Yes |
| C3 | 5.65 | 2 | Yes |
| C4 | 5.07 | 1 | Yes |
| C5 | 6.46 | 1 | Yes |
| Avg | 5.96 | 1.6 ± 0.4 | |
| SS1 ΔhylB::cat-D1 | |||
| H1 | 5.52 | 1 | No |
| H2 | 6.41 | 1 | Yes |
| H3 | 5.97 | 2 | Yes |
| H4 | 5.94 | 3 | Yes |
| H5 | 7.39 | 1 | Yes |
| Avg | 6.77 | 1.6 ± 0.4 | |
| Uninfected | |||
| U1 | 0 | 0 | No |
| U2 | 0 | 0 | No |
a
C57BL/6 mice were used for these infections. All grading was done using a stomach sample that included both the antrum and the corpus. All mice were also graded for gastric atrophy and had a score of 0.
b
Average ± standard error of the mean.