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Effect of supplementation with α-aminoadipate on cephamycin production by wild-type and pcd::apr mutant strains of S. clavuligerus grown on soy medium
| Culture | Cephamycin productiona [μg/ml (μg/mg DNA)]
|
|
|---|---|---|
| No α-aa | +5 mM α-aa | |
| Wild type | ||
| 72 h | 188 (903) | 240 (1,030) |
| 96 h | 140 (645) | 181 (939) |
| pcd::apr-B3 | ||
| 72 h | 80 (334) | 256 (998) |
| 96 h | 75 (396) | 155 (787) |
Cultures were grown in triplicate for each time point. Each sample was assayed in duplicate; data represent averages. α-aa, α-aminoadipate.
