FIG. 1.

Organization of the human serpin gene cluster on chromosome 14q32.1. The serpin cluster in humans on chromosome 14q32.1 is composed of 11 genes (2 pseudogenes and 9 expressed genes). Previous work demonstrated the presence of 5 matrix attachment regions and 17 expression-associated and 8 constitutive DHSs in rat hepatoma cells. The positions of the ChIP and nongenic transcript PCR amplicons used in this study are indicated. KAL, kallistatin gene; AACT, α1-antichymotrypsin gene; PCI, protein C inhibitor gene; ψATR, antitrypsin-related pseudogene; 1ATpM, macrophage α1AT gene promoter; α1ATpH, hepatic α1AT gene promoter; CBGp, CBG gene promoter.