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. 2007 May 25;27(15):5286–5295. doi: 10.1128/MCB.00176-07

FIG. 5.

FIG. 5.

Excision of the HNF3β-HNF6α binding region at the kb −7.5 DHS results in decreased expression of the proximal cluster. (A) Illustration of the α1AT gene and the URR, including DHSs and the HNF-6α binding site at kb −7.5. The region removed by the Δ461/−7.8 modification is indicated. α1ATpM, macrophage α1AT gene promoter; α1ATpH, hepatic α1AT gene promoter. (B) The expression of the α1AT (PI), CBG, and ZPI genes in F(461wt n) and F(Δ461/−7.8) cells was measured via AQPCR. Levels of expression were normalized according to that in F(461wt n) cells and displayed as a percentage of that in the control hepatoma cell line. The average levels of expression (± standard deviations) from three independent AQPCR experiments are shown.