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Embryonic and postnatal phenotypes of Mdm2+/− Mdm4+/− mice. (A) Twenty percent of Mdm2+/− Mdm4+/− embryos show exencephaly associated with cleft palate or other neural tube defects. WT, wild type. (B) Delay in postnatal development of Mdm2+/− Mdm4+/− mice compared to wild-type mice. (C) Weights of mice with various genotypes during early postnatal development. (D) Complete blood counts for 13-day-old wild-type and Mdm2+/− Mdm4+/− pups.
