Table 1. HIV-1 nonamers with high similarities to human proteins.
Significant 9-mers consensus 2001 | Human Protein sequence | Human protein | HIV database seq. corresponding to human prot. seq. | HIV-I B consensus 2001 position | Identities (Positives) |
LHPVHAGPI | LnPVHAGPIV | PTPRE | Gag 215–223 | 9/10 (10/10) | |
LHPGHAEPIV | T cell leukemia Homeobox 1 | LHPVHAEPI | 8/10 | ||
EPFRDYVDRF | VPFRDYVDR | COPINE 5 | AAV71076 | Gag 291–300 | 8/9 |
PFRDYVDRS | AAV53244 | 8/9 | |||
PDCKTILKA | HPDCKTI | DELTEX 4 homolog | AAV49378 | Gag 328–336 | 7/7 |
NTPVFAIKKK | SPWNTPVFVIKKK | HERV | PYNTPVFVIKKK | Pol 209–221 | 11/13 |
MTKILEPFR | MTKILEPC | Piwi-like 2 | AAM74596 | Pol 319–327 | 7/8 |
sMTKILDSF | SON DNA Binding P. | AAK35877 | 6/9 (7/9) | ||
FKNLKTGKY | FKNSKTG | Str Spe Recognition P. | FKNNKT | Pol 501–508 | 6/7 |
VNIVTDSQYA | VNIYTDSQYA | HERV | VNIITDSQYA | Pol 648–657 | 9/10 |
VNTVTDDDYA | Thrombospondin 3 precursor | VNIVTDsEYA | 7/10 | ||
YIEAEVIPA | GYIEAAVIPAG | unnamed P. | Pol 798–806 | 10/11 | |
EIEAEV | p53 inducibleP. | AAV49469 | 6/6 | ||
NWRSELYKY | HNWRSELY | peroxysomal acylcoA thioestherase | CAA64162 | Env 469–477 | 7/8 |
AAG…TVW | 35/37 | Cancer associated RAK | Env 516–572 | 35/37 | |
DQGPQREPY | qRP–DQGPQRPP | carcinoma ass. P. | DQGPQRAP | Vpr 7–15 | 9/13 (10/13) |
DQGPQRPP | proline rich | 7/8 | |||
PKTACTNCY | SQPKsACGNCY | Zn finger P. | SQPKtACSNCY | Tat 18–26 | 9/11 (10/11) |
LAIVALVVA | ALVALVVAPL | Trypsin-domain P. | ALVALVVAVL | Vpu 7–15 | 9/10 |
LAIVALAV | small inducible cytokine 28 | 7/8 | |||
EELLKTVRL | EELLKEVRL | nucleolar RNA associated P. | EELLKAVRL | Rev10–18 | 8/9 |
LLKTVRLLRLL | LLKTVRLiRLL | 10/11 | |||
TVRERMRRA | TTVRSRMRRA | Rhomboid P. | Nef 15–23 | 9/10 | |
IYSQKRQDI | TYSQKFQDI | Ig heavy chain variable region | TYSQKRQDI | Nef 101–109 | 8/9 |
The level of similarity to host proteins for these HIV nonamers differed by 3 standard deviations from the level of similarity found with randomized nonamers. Amino acid changes are in bold italics and lower case.