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. 2007 Sep 5;2(9):e823. doi: 10.1371/journal.pone.0000823

Table 1. HIV-1 nonamers with high similarities to human proteins.

Significant 9-mers consensus 2001 Human Protein sequence Human protein HIV database seq. corresponding to human prot. seq. HIV-I B consensus 2001 position Identities (Positives)
LHPVHAGPI LnPVHAGPIV PTPRE Gag 215–223 9/10 (10/10)
LHPGHAEPIV T cell leukemia Homeobox 1 LHPVHAEPI 8/10
EPFRDYVDRF VPFRDYVDR COPINE 5 AAV71076 Gag 291–300 8/9
PFRDYVDRS AAV53244 8/9
PDCKTILKA HPDCKTI DELTEX 4 homolog AAV49378 Gag 328–336 7/7
NTPVFAIKKK SPWNTPVFVIKKK HERV PYNTPVFVIKKK Pol 209–221 11/13
MTKILEPFR MTKILEPC Piwi-like 2 AAM74596 Pol 319–327 7/8
sMTKILDSF SON DNA Binding P. AAK35877 6/9 (7/9)
FKNLKTGKY FKNSKTG Str Spe Recognition P. FKNNKT Pol 501–508 6/7
VNIVTDSQYA VNIYTDSQYA HERV VNIITDSQYA Pol 648–657 9/10
VNTVTDDDYA Thrombospondin 3 precursor VNIVTDsEYA 7/10
YIEAEVIPA GYIEAAVIPAG unnamed P. Pol 798–806 10/11
EIEAEV p53 inducibleP. AAV49469 6/6
NWRSELYKY HNWRSELY peroxysomal acylcoA thioestherase CAA64162 Env 469–477 7/8
AAG…TVW 35/37 Cancer associated RAK Env 516–572 35/37
DQGPQREPY qRP–DQGPQRPP carcinoma ass. P. DQGPQRAP Vpr 7–15 9/13 (10/13)
DQGPQRPP proline rich 7/8
PKTACTNCY SQPKsACGNCY Zn finger P. SQPKtACSNCY Tat 18–26 9/11 (10/11)
LAIVALVVA ALVALVVAPL Trypsin-domain P. ALVALVVAVL Vpu 7–15 9/10
LAIVALAV small inducible cytokine 28 7/8
EELLKTVRL EELLKEVRL nucleolar RNA associated P. EELLKAVRL Rev10–18 8/9
LLKTVRLLRLL LLKTVRLiRLL 10/11
TVRERMRRA TTVRSRMRRA Rhomboid P. Nef 15–23 9/10
IYSQKRQDI TYSQKFQDI Ig heavy chain variable region TYSQKRQDI Nef 101–109 8/9

The level of similarity to host proteins for these HIV nonamers differed by 3 standard deviations from the level of similarity found with randomized nonamers. Amino acid changes are in bold italics and lower case.