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Improved insulin action in Grb10Δ2-4 mutant mice. Results of i.p. ITT for male (A) and female (B) mice at 17 to 21 weeks of age who fasted overnight (left panels) are shown, with Grb10Δ2-4m/+ (M-het), and Grb10Δ2-4m/p (Ko) animals compared to wild-type (Wt) controls. The incremental areas under the glucose curves are shown (right panels). All results are expressed as means ± SEM (**, P < 0.05; ***, P < 0.001 [ANOVA]).
