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Stabilization of HIF under normal oxygen conditions is sufficient to increase hTERT transcription and telomerase activity. HIF-1α protein levels (a), relative hTERT mRNA levels normalized to the ribosomal protein L19 (b), and telomerase activity (c) in PHLF exposed to 21% O2, PHLF infected with adenovirus encoding the ODDDwt or ODDD(P564A) of HIF-1α (amino acids 531 to 575) in 21% O2, or PHLF in 1.5% O2 *, P < 0.05 for ODDDwt compared to ODDD(P564A) (n = 3).
