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HIF is sufficient for the increase in replicative life span. PHLF cells with activated endogenous HIF were generated by stably expressing the ODDDwt construct, with ODDD(P564A) as a control. Transcriptional activity of HIF (a) and PDs (b) were monitored under 21% O2 at the indicated days postinfection. * P < 0.05 for ODDDwt compared to ODDD(P564A) (n = 3).
