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Loss of the pVHL tumor suppressor protein that regulates HIF increases replicative life span in PHLF. (a) pVHL protein levels from whole-cell lysates of PHLF stably expressing an shRNA against pVHL. (b) HIF-1α protein levels in cells stably expressing shRNA for dHIF and pVHL that were exposed to 21% O2 or 1.5% O2. N, normoxia; H, hypoxia. (c) PHLFs expressing an shRNA against pVHL or dHIF (control) were grown in 21% O2, and their PDs were monitored postinfection.
