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. 2007 Jun 4;27(16):5849–5859. doi: 10.1128/MCB.00802-07

FIG. 3.

FIG. 3.

Mice with hypomorphic alleles of Pgm3 exhibit a profound B lymphopenia associated with a defect at the pro-B-cell-to-pre-B-cell transition. (A) Bone marrow cells from 60- to 80-day-old Pgm3+/+, Pgm3mld1/mld1, and Pgm3mld1/gt mice were analyzed by FACS for the expression of B220 and CD43. Data shown are representative of data from at least five age-matched mice. (B) Splenocytes from 60- to 80-day-old Pgm3+/+, Pgm3mld1/mld1, and Pgm3mld1/gt mice were analyzed by FACS for the expression of B220 and IgM. Data shown are representative of data from at least five age-matched mice. (C) Lymph node cells from 60- to 80-day-old Pgm3+/+, Pgm3mld1/mld1, and Pgm3mld1/gt mice were analyzed by FACS for expression of IgD and IgM. Data shown are representative of data from at least five age-matched mice. (D) Spleens of Pgm3mld1/mld1 and Pgm3mld1/gt mice display expansion of the red pulp and an absence of lymphoid follicles.