FIG. 3.

Smad7 expression increases the proliferation rate of Off*Ahr^−/− cells but not that of Off*Ahrb cells. Cells were infected with 200 PFU per cell of an adenoviral vector expressing Smad7, a multiplicity of infection previously determined to infect greater than 95% of the cells. Flow cytometric determinations were carried out for uninfected cells and in cells infected for 24 and 48 h. The fractions of cells in G₀/G₁, S, and G₂/M are indicated in each panel. The differences between infected and uninfected Off*Ahr^−/− cells, but not those of Off*Ahrb cells, are significant (P < 0.05).