Figure 4. Glutamine increases the size of primary evoked potentials in control and undercut cortex.

Measurements of mean primary evoked response area (mV × ms) from control and undercut slices demonstrate larger potentials in the undercut slices in the absence of glutamine. Addition of glutamine leads to increases for both with the size of the potentials increasing with glutamine concentrations of up to 1mM. At concentrations of 500μM and above glutamine induced spreading depression like events in undercut cortex and precluded an appropriate analysis. Data were collected from four independent slices for each group. The primary evoked response was defined as that occurring within 50 μs of the stimulus.