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. Author manuscript; available in PMC: 2007 Aug 24.
Published in final edited form as: Neurobiol Dis. 2006 Oct 27;25(2):230–238. doi: 10.1016/j.nbd.2006.08.025

Figure 5. Glutamine and MeAIB have opposing effects on the likelihood of polyphasic potentials in undercut cortex.

Figure 5

Sample evoked potentials from undercut cortex field recordings (A) demonstrate a simple monophasic response either without (failure, left) or with (success, right) a late polyphasic response. B) Incidence of polyphasic events in undercut slices in response to varying interstimulus intervals (ISIs). Slices were exposed to either 250μM glutamine or 250μM glutamine with 10mM MeAIB in the ACSF (n=5 from 4 animals). Addition of glutamine increased the incidence of polyphasic events causing a leftward shift in the curve indicating a decrease the refractory period. By contrast, addition of MeAIB almost completely blocked polyphasic activity. C) The interval evoking 50% successes (ISI-50) was consistently shortened by 250 μM glutamine, as shown in this paired analysis. The ISI-50 decreased from 8.2 seconds to 5.9 seconds. Student's two-tailed t-test p<0.01, n=8 slices from 4 animals.