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. Author manuscript; available in PMC: 2008 Jul 1.
Published in final edited form as: Dev Biol. 2007 Apr 27;307(1):114–126. doi: 10.1016/j.ydbio.2007.04.027

Fig. 6. Hand2 regulates TH and DBH in the SNS.

Fig. 6

Noradrenergic differentiation was investigated by immunocytochemical analysis of the expression of the catecholamine biosynthetic enzymes, TH and DBH. The immunoreactivities of TH (A, B) and DBH (C, D) were analyzed in sections of the abdominal region of 12.5 dpc embryos in wild-type (A, C) and Hand2loxP/−; Wnt1-Cre (B, D) embryos. E: The level TH and DBH was quantified relative the level of expression of the pan-neuronal marker TuJ1 by density determination of immunoreactivity. The level of TH expression was reduced 10 fold and DBH by 8 fold in mutant sympathetic neurons.