Fig. 4.

Reduced male fertility and testis weight in Foxa3-deficient mice. a) The testicular defect in Foxa3-deficient mice results in reduced fertility. Male age-matched mice of each genotype were housed together with a female CD1 wt mouse. The average litter size in the mutant (p<0.05) and in the heterozygous group (p<0.02) was significantly lower than in the wt group. b) The Foxa3-mutant (p=0.003) as well as the heterozygous (p=0.007) mice show a significantly reduced testis weight compared to the wild type controls. Data are presented as paired testis weight [mg] per body weight [g].