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. Author manuscript; available in PMC: 2007 Aug 27.
Published in final edited form as: Annu Rev Immunol. 2007;25:619–647. doi: 10.1146/annurev.immunol.25.022106.141618

Figure 2.

Figure 2

A mutant, high-affinity αL I domain (gold β-sheet and coil and green α-helices) in complex with domain 1 of ICAM-3 (cyan). The Mg2+ is shown as a gray sphere. The side chain of the key integrin-binding residue, Glu37 of ICAM-3, is shown. The mutationally introduced K287C/K294C disulfide bond that stabilizes the open conformation is shown in pink. ICAM-3 domain 2 is omitted for clarity. [From Protein Data Bank (PDB) ID code 1T0P (7).]