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. Author manuscript; available in PMC: 2007 Aug 27.
Published in final edited form as: Anesthesiology. 2007 Jul;107(1):82–90. doi: 10.1097/01.anes.0000267502.18605.ad

Figure 3. Use-dependent block of Na+ currents by BLA and by aconitine.

Figure 3

(A) Superimposed traces of Na+ currents were recorded in the presence of 10 μM BLA with 1,000 repetitive pulses (+50 mV for 4 ms) applied at 2 Hz. The cell was perfused with 10 μM BLA ~5 min before repetitive pulses. Current traces are labeled with the number of corresponding pulses, ranging from 1P to 1000P. (B) Superimposed traces of Na+ currents were recorded in the presence of 10 μM aconitine with 1,000 repetitive pusles. The conditions were the same as described in (A).