Table 2. Relative areas under the curves (AUC) for sensory and motor block of the sciatic nerve.

The AUCs of individual rats (e.g., Fig. 5–7 for averaged data) were integrated and the values (in score x time) for sensory and motor block are listed. Epinephrine was diluted to 1:100,000. One-way analysis of variance (ANOVA) was used to test for overall mean differences of AUCs in 2% lidocaine, 0.375 mM BLA, 0.375 mM BLA plus 2% lidocaine, and 0.375 mM BLA plus epinephrine groups. Given a significant F test (P < 0.05), pairwise post-hoc Bonferroni tests were performed for multiple pairwise comparisons.

Drug injected	N	AUC for sensory block	AUC for motor block
2% lidocaine 0.375mM BLA 0.375mM BLA + 2% lidocaine 0.375mM BLA + Epinephrine	6 6 6 6	148.33 ± 21.51 405.83 ± 26.25* 755.00 ± 45.61**,‡‡ 1048.33 ± 62.22**,‡‡	156.67 ± 20.11 423.33 ± 34.22* 755.00 ± 45.61**,‡‡ 725.00 ± 51.58**,‡‡
0.75mM BLA + 2% lidocaine 0.75mM BLA + Epinephrine	6 6	1235.00 ±150.73† 1011.67 ± 98.14	1125.00 ±135.72† 875.00 ± 56.21

^*P < 0.01,

^**P < 0.001 (with F[3,20]=87.52 for sensory and 50.35 for motor), compared to 2% lidocaine group.

^‡‡P < 0.001 (with F[2,15]=46.74 for sensory and 17.08 for motor), compared to 0.375mM BLA group. The GEE statistic analyses likewise supported these conclusions. An unpaired Student’s t test was used to evaluate mean differences of AUCs between 0.75 mM BLA plus 2% lidocaine and 0.375 mM BLA plus 2% lidocaine,

^†P < 0.05 was considered statistically significant. No statistical significance in AUC was found between 0.375 mM with epinephrine and 0.75 mM BLA with epinephrine.