Table 2.
Effects of systemically administered drugs on male mouse and hamster sexual behavior
| TRANSMITTER ALTERING DRUGS | EFFECTS ON SEXUAL BEHAVIOR | REFERENCES | REMARKS |
|---|---|---|---|
|
Dopaminergic:
-DA agonists: -DA antagonist |
+ − |
Mice: ( Sugiura et al., 1997; Rampin et al., 2003; Niikura et al., 2002; Sczypka, 1998) Mice: (Lopez & Ettenberg, 2002b) |
DA-deficient mice were activated by L-DOPA and were more sensitive to L-DOPA and T (Sczypka et al., 1998). |
|
Noradrenergic:
-NE agonists: |
+ |
Hamsters: (Arteaga et al., 2002) |
Increasing NE release with an α2 autoreceptor agonist facilitated copulation. |
|
Serotonergic:
-5-HT1A Agonists: -5-HT1B Agonists: -5-HT reuptake inhibitor |
− − − |
Mice: (Rodriguez-Manzo, 2002; Popova and Amstislavskaya, 2002)
Hamsters: (Boscarino & Parfitt, 2002) |
5-HT1B knock-out mice were less impaired by serotonergic drugs, but needed more stimulation to ejaculate, possibly because of compensatory mechanisms (Rodriguez-Manzo, 2002). |
|
Nitric Oxide:
-nNOS knock-outs: -NO antagonists: |
− − |
Mice: (Burnett et al., 1996; Kriegsfeld et al., 1999) |
nNOS knockouts had normal erections, due to increased eNOS, but ejaculated with fewer intromissions; thus NO may help prevent “premature ejaculation.” |
|
GnRH:
-GnRH icv |
+ |
Hamsters: (Fernandez-Fewel and Meredith, 1995) |
GnRH is released in response to female hamster odor. |