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. 2007 Sep 4;117(9):2369–2376. doi: 10.1172/JCI33099

Figure 4. Requirement of miR-208 for cardiomyocyte hypertrophy and fibrosis.

Figure 4

(A) Schematic diagram of a heart following thoracic aortic banding (TAB). (B) Sections of hearts of approximately 3-month-old wild-type and miR-208–/– mice are shown following sham operation or TAB for 21 days. High-magnification views of the ventricular wall are shown at the bottom. Trichrome staining identifies fibrosis in blue. Note that hypertrophy and fibrosis are diminished in miR208–/– mice compared with wild-type following TAB. Scale bars: 2 mm (top); 20 μm (bottom). Reproduced with permission from Science (5).