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Effects of the MEK inhibitor, PD98059, on NGF-mediated p21Cip1/WAF1 induction and changes in cyclin expression. Levels of p21Cip1/WAF1 (A) or cyclin proteins involved in the activation of CDK2 and CDK4 (B) were analyzed by Western blot analysis of whole cell lysates (20) following treatment with NGF (20 nM) or with a combination of NGF and the MEK inhibitor, PD98059 (40 μM) for 16 hr. Similar results were found in at least three independent experiments.
