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. 1997 Jan 21;94(2):459–462. doi: 10.1073/pnas.94.2.459

Figure 1.

Figure 1

Glutamate corresponding to E974 of GC-A is conserved in guanylyl and adenylyl cyclases. The alignment of a sequence within the catalytic domain of GC-A is shown as an example of a membrane guanylyl cyclase isoform, the α1 and β1 subunits of the soluble isoform, and the first and second cytoplasmic domain (C1 and C2) of adenylyl cyclase IV. The corresponding amino acids are 957–977 (GC-A), 590–610 (α1), 537–557 (β1), 383–403 (adenylyl cyclase IV, C1), and 990-1010 (adenylyl cyclase IV, C2).