Figure 8.

Histology of tumors induced by 16-kDa N-terminal IL-1α propiece transfected cells (hematoxylin/eosin stain). (A) The tumors display the same growth patterns observed in vitro, consisting of elongated, spindle-like cells, with a second epithelioid cell in the interstices. (B) The tumor were highly invasive, with extensive infiltration of all visceral organs, including the liver shown here (arrows), and demonstrated exuberant neovascularization with palisading endothelial cells (C). (A and C, ×500; B, ×330.)