Figure 1 Cortistatin (CST) decreases the severity of collagen‐induced arthritis. DBA1 mice with established CIA were injected intraperitoneally (arrow) either with phosphate‐buffered saline (control) or with different doses of CST (2 nmol/mouse for left panel) daily for five days or with a single administration (pulse) on day 25. The severity of arthritis was assessed by clinical scoring. Numbers in parenthesis are the frequency of arthritis (percentage of mice with an arthritis score >2 at day 50). Images show representative examples of the paw swelling in mice of the different experimental groups. n = 8–16 mice per group. p<0.001 versus control for 1, 2, 5 and 10 nmol CST treatments after day 32.