Figure 2 Cortistatin (CST) ameliorates the histopathology of collagen‐induced arthritis (CIA). DBA1 mice with established CIA were injected intraperitoneally either with phosphate‐buffered saline (control) or with CST (2 nmol/mouse) daily for five days after day 25 post immunisation. Histological analysis of trichrome‐stained (upper) or H&E‐stained (lower) sections of joints obtained at day 45 was performed. Arrows point to osteoclasts destroying bone. Scoring of inflammation, cartilage damage and bone erosion of paws from untreated (control) and CST‐treated CIA mice is shown. Neutrophil infiltration in the joints was determined by measuring myeloperoxidase (MPO) activity in protein extracts isolated at day 35. *p<0.001 versus control.